08 Oct 2025 Updated ACIP Recommendations and MMRV Vaccine

On September 18-19, 2025, CDC’s Advisory Committee on Immunization Practices (ACIP) voted to recommend:

• MMRV (combined MMR + varicella) vaccine should not be given to children under 4 years old.
  • It is recommended to administer MMR and varicella vaccines separately.

Clinical Background: MMRV Vaccine

The MMRV vaccine is a combination vaccine against measles, mumps, rubella, and varicella. The ACIP made this decision on the basis that the MMRV vaccine is linked to a twofold increased risk of febrile seizures in children under 2. According to national data, MMRV vaccine accounts for about 15% of first dose measles, mumps, and rubella vaccination. In Philadelphia, MMRV as first dose accounts for even less than the national average.

Implications for Vaccine Access 

• Vaccines for Children (VFC) coverage: MMRV vaccine will no longer be covered for children under 4 years old through the VFC program. MMRV vaccine will continue to be covered for children 4 to 12 years of age.
• Clinical guidance: Immunization decisions should continue to be made by clinicians and families based on the most current eligibility criteria.
  • Children should still receive two doses of measles, mumps and rubella (MMR) and varicella vaccines — once at 12 to 15 months and again at 4 to 6 years as per the childhood vaccination schedule.
  • MMR and varicella vaccines can be given at the same visit.
  • Children aged 4 years and older can still get MMRV. There is no evidence of an increased risk of febrile seizure in this older age group. 

Questions?

• For product availability questions: dphproviderhelp@phila.gov 
• For all other inquiries: vaccines@phila.gov

The Philadelphia Immunization Program remains committed to protecting children and families from vaccine-preventable diseases. We will continue to keep you informed on vaccine availability, product coverage, and resources to support your practice and patients.