13 Mar 2026 Continue Offering RSV Monoclonal Antibody Immunization Until April 15, 2026

Increased disease activity indicates season extension

The Philadelphia Department of Public Health recommends offering RSV monoclonal antibody immunization (i.e., nirsevimab and clesrovimab) to all eligible patients until April 15, 2026 due to continued RSV hospitalizations. 

Federally purchased RSV immunization will no longer be available to order after March 31, 2026. In order to ensure adequate supply, be sure to place RSV immunization orders by Friday, March 27, 2026.

The Centers for Disease Control and Prevention (CDC) is reporting a national shift in RSV epidemiology for the 2025-2026 season. This RSV season began later than usual and activity continues to be higher than what is typically seen at this time of year, as is reflected in sustained test positivity, emergency room visits, and hospitalizations. This indicates that the current RSV season will likely extend into April 2026. Most hospitalizations are occurring in the 0-2 year age group. Severity has not increased and peak activity remains lower than what was seen in the 2024-2025 season.

In Philadelphia, RSV test positivity remains significantly above 3%, with continued higher-than-average hospitalizations seen across all age groups. While hospitalizations are decreasing, young children continue to be at risk for severe RSV. 

Recommendations & Product Availability

Given these trends and CDC recommendations to adjust seasonal RSV immunization based on local activity, the Philadelphia Department of Public Health is recommending extending RSV monoclonal antibody immunization (i.e., nirsevimab and clesrovimab) for newborns and infants until April 15, 2026. Guidance will be updated based on continued RSV disease activity surveillance. 

Currently, there is no recommendation to modify maternal RSV vaccination given at 32-36 weeks’ gestation beyond the window of September through January of a pregnancy.  

RSV immunizations have been remarkably effective in decreasing RSV-associated hospitalizations in infants.   

Both RSV monoclonal antibody immunizations are available for birth hospitals and outpatient clinics to order through the Vaccines for Children (VFC) program. Place RSV immunization orders by Friday, March 27, 2026 in order to continue offering immunization until April 15.

For questions, contact our ordering team at DPHProviderHelp@phila.gov.