Monkeypox

Monkeypox Inventory Update and Ordering Cadence

To facilitate the transition to intradermal (ID) administration of the Jynneos Monkeypox (MPX) vaccine, please:

Accept all Monkeypox inventory into your inventory location. Use this guide.
Complete an inventory reconciliation titled “SubQ to ID Transition,” so that we have an accurate count of the number of vials you have on hand. Use this guide.
Email vaccines@phila.gov when the reconciliation is complete so PDPH staff can update your inventory to reflect the number of ID doses you have on hand.

Beginning Monday 08/22, we are moving to a weekly ordering cadence for the MPX vaccine.Providers will need to enter orders by 5 pm on Mondays. If your request is approved, you can expect to receive MPX doses Wednesday or Thursday following your request date.Please remember for your request to be approved you must:

Upload your temperature logs to PhilaVax or email them to tempcheck@phila.gov.
Report wasted doses in PhilaVax. Because Jynneos is licensed for one dose per vial, wastage will be considered as any wastage of a full vial of vaccine for any reason. See wastage reporting instructions here and additional wastage guidance here.
Submit your reconciliation in PhilaVax. A reconciliation guide can be found here.
Find the order form here.

Additional Resources

Need a refresher on the Inventory Module in PhilaVax? Find a video guide here.
Use this dose tracker to track JYNNEOS administration at your practice.

If you have questions about accessing MPX vaccine, email vaccines@phila.gov.

Monkeypox Update: Switch to JYNNEOS Intradermal Strategy

Due to a shortage of doses, the PDPH recommends that providers switch to intradermal vaccination as soon as possible.

Intradermal administration involves injecting the vaccine superficially between the epidermis and the hypodermis layers of the skin, typically of the inner side of the forearm.

Intradermal JYNNEOS administration can be considered for most adults ages 18 years and older. Exceptions include people with a history of developing keloid scars. It is also recommended that clinicians observe patients after vaccination to monitor for the occurrence of immediate adverse reactions; 15 minutes is suggested for most patients, 30 minutes for persons with a history of anaphylaxis to gentamicin, ciprofloxacin, chicken, or egg protein.

Vaccine Schedule and Dosing Regimens

While JYNNEOS dose availability is currently limited, the recommendation is for providers to begin with a single shot. When there is enough vaccine to administer two shots (a complete dose), the recommended dosing interval between the first and second dose of JYNNEOS vaccine for both the standard (subcutaneous administration) and the alternative (intradermal administration) dosing regimens is 28 days for both.

For further questions, email vaccines@phila.gov.