{"id":13193,"date":"2025-11-14T14:34:48","date_gmt":"2025-11-14T19:34:48","guid":{"rendered":"https:\/\/vaccines.phila.gov\/?p=13193"},"modified":"2025-11-14T14:34:50","modified_gmt":"2025-11-14T19:34:50","slug":"updated-clinical-guidance-for-covid-19-vaccine","status":"publish","type":"post","link":"https:\/\/vaccines.phila.gov\/index.php\/updated-clinical-guidance-for-covid-19-vaccine\/","title":{"rendered":"Updated Clinical Guidance for COVID-19 Vaccine"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The CDC released updated clinical guidance for the 2025-2026 COVID-19 vaccine.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Previously, all unvaccinated children younger than 5 years were recommended to receive 2 doses of 2025-2026 Moderna vaccine as their primary series.<br><br>\n<ul class=\"wp-block-list\">\n<li><strong>Now, children aged 6-23 months who are unvaccinated are recommended to receive 2 doses as their primary series. In addition, children aged 6-23 months who previously received 1 dose of Pfizer vaccine should also receive 2 doses of 2025-2026 Moderna vaccine.\u00a0<\/strong>As a reminder, Pfizer vaccine is no longer available for children aged 6 months-4 years.\u00a0<\/li>\n\n\n\n<li><strong>It is also recommended that children aged 2 years (24 months) and older receive only 1 dose of the 2025-2026 Moderna vaccine, even if previously unvaccinated.\u00a0<\/strong><\/li>\n\n\n\n<li><strong>If given 2025-2026 Novavax vaccine, children aged 12+ are recommended to receive 1 dose, even if previously unvaccinated.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Review the tables (previewed below)&nbsp;<a rel=\"noreferrer noopener\" target=\"_blank\" href=\"https:\/\/gcc02.safelinks.protection.outlook.com\/?url=http%3A%2F%2Furl4461.phila.gov%2Fls%2Fclick%3Fupn%3Du001.iSzM8kOxQHA1M7bVE116qpvMcTsLaSTWfYOO-2Bl5W5hP3c01NyKMzG8DgAmhDfnXQl-2Bw4WRChrr1HEH3yWAWJtKmpQ0M-2BYNAttPFWiVpS8SEd2IYbelOQdtsJeGuc9MfjuJ9s-2BV8PCmA96QrMV62lkw-3D-3DacBa_44-2B2VrTxhhp9EIC5J97IR8LrDLL7-2FOtjCS1FCFHr2guUpXwn9J3ycSqZHyo-2FRwPe0AZdxd0PYzIEfiASJ5xII-2FDX94yyZOVcOzUIqeX2nmogSxJd8iEa9-2BLj5DyGgO1qVYwvVfaMZajDkTw5ZyENsU6CZP-2B124jceh37-2BAK9skFHyG8M6IUFixK2g5puV3WHkaN0QO9jFUdCGPIaX0dgvJ0lG2A8DZNQBuO5U5kV-2Bzd7mhhnYKqWzUGgWnie0Ur0BWKwkNIRMreUyAzidvwAr3ieY3sjoTppsTzAehirOLIanpzVvAytUryc8eTEH-2Fd5OHUh82OQmwlkCDZy-2B5LGFhZUw1ZtqrirSZW3zSU6-2FHJIzqPpgKJd-2FdprdK65M2aVgN-2BcUg-2FB81C9pXODMxfPHAKVNGXnVcq-2FeZodl6L7jc1GHChRaPWbRN5Z1GxbvJZHFjDm9qi62aPOIbMMmZbTarirC84MD-2FSZ3Nh1g0CZ0xjkT83cWi5D3TqrwQxWYJE2wPuDX28DSCbDnBHQ7xdTBOrzc510MxAgSNZqBIzhoOaT26Y9d90hDGlKeV8jsZtj9oCyyBIv2UBVDofPXd-2Bv08XqGjlsnPbmUqgXzpzASS9RyJGn0PS7oVRadXGNqK1qPZFKhRWOBDiO-2B30Wquzi1tO4ngOBz7-2BTAuEcZGtua6K0RHfi19gsEvaOi-2FfTe7UrYY4joxx3s4l5kC0Bus-2FHz0mU4CFnIaFUhUw-2B0Z0pFJOMktHdoApq9U-2FmzRH9J41b3nToy0BQord4Tiu-2B4uPx-2FjYvR4b8716WkHzjbLv1-2FuLYfU3abL9KG4m2p1SDDrV-2BtdkCMMC-2BLK07FPKDSRa9RaenZgvHG3IH15HtnLXH-2FnjTqiZuyH84qZFykT3YL0qp5uUUgemjer4utD31hHhzaQ-3D-3D&amp;data=05%7C02%7Crishi.sharma%40phila.gov%7C19444e0842ed4c1d304508de23a7d0de%7C2046864f68ea497daf34a6629a6cd700%7C0%7C0%7C638987400834346610%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=kxJcTQhTRIvM3ml%2Fp2HLrp1CtI5SzVjUaESUhRKsLdI%3D&amp;reserved=0\"><u><strong>on this CDC webpage<\/strong><\/u><\/a>&nbsp;for a deeper dive into these changes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"773\" height=\"418\" src=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028.png\" alt=\"\" class=\"wp-image-13194\" srcset=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028.png 773w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028-480x260.png 480w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028-700x379.png 700w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028-300x162.png 300w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028-600x324.png 600w\" sizes=\"auto, (max-width: 773px) 100vw, 773px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"675\" src=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-1024x675.png\" alt=\"\" class=\"wp-image-13195\" srcset=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-1024x675.png 1024w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-480x317.png 480w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-700x462.png 700w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-300x198.png 300w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529-600x396.png 600w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092529.png 1140w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"142\" src=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-1024x142.png\" alt=\"\" class=\"wp-image-13196\" srcset=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-1024x142.png 1024w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-480x67.png 480w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-700x97.png 700w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-300x42.png 300w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551-600x83.png 600w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092551.png 1129w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"816\" height=\"366\" src=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213.png\" alt=\"\" class=\"wp-image-13197\" srcset=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213.png 816w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213-480x215.png 480w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213-700x314.png 700w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213-300x135.png 300w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093213-600x269.png 600w\" sizes=\"auto, (max-width: 816px) 100vw, 816px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"418\" src=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-1024x418.png\" alt=\"\" class=\"wp-image-13198\" srcset=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-1024x418.png 1024w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-480x196.png 480w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-700x286.png 700w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-300x122.png 300w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618-600x245.png 600w, https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-092618.png 1139w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.cdc.gov\/covid\/hcp\/vaccine-considerations\/routine-guidance.html#heading-od-jmebm1w\">Review the updated guidance<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For any questions about this updated guidance, please contact us at\u00a0<a href=\"mailto:vaccines@phila.gov?subject=&amp;body=\"><strong>vaccines@phila.gov<\/strong><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The CDC released updated clinical guidance for the 2025-2026 COVID-19 vaccine. Review the tables (previewed below)&nbsp;on this CDC webpage&nbsp;for a deeper dive into these changes. For any questions about this updated guidance, please contact us at\u00a0vaccines@phila.gov.<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,137,1],"tags":[],"class_list":["post-13193","post","type-post","status-publish","format-standard","hentry","category-medical-directors-notes","category-covid-19","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Updated Clinical Guidance for COVID-19 Vaccine - Philadelphia Immunization Program<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vaccines.phila.gov\/index.php\/updated-clinical-guidance-for-covid-19-vaccine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Updated Clinical Guidance for COVID-19 Vaccine - Philadelphia Immunization Program\" \/>\n<meta property=\"og:description\" content=\"The CDC released updated clinical guidance for the 2025-2026 COVID-19 vaccine. Review the tables (previewed below)&nbsp;on this CDC webpage&nbsp;for a deeper dive into these changes. For any questions about this updated guidance, please contact us at\u00a0vaccines@phila.gov.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/vaccines.phila.gov\/index.php\/updated-clinical-guidance-for-covid-19-vaccine\/\" \/>\n<meta property=\"og:site_name\" content=\"Philadelphia Immunization Program\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/phillyhealth\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-14T19:34:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-14T19:34:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/vaccines.phila.gov\/wp-content\/uploads\/2025\/11\/Screenshot-2025-11-13-093028.png\" \/>\n\t<meta property=\"og:image:width\" content=\"773\" \/>\n\t<meta property=\"og:image:height\" content=\"418\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Rishi Sharma\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rishi Sharma\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/\"},\"author\":{\"name\":\"Rishi Sharma\",\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/#\\\/schema\\\/person\\\/d7a8d2d210d1cf6f6d8ac87325b45e54\"},\"headline\":\"Updated Clinical Guidance for COVID-19 Vaccine\",\"datePublished\":\"2025-11-14T19:34:48+00:00\",\"dateModified\":\"2025-11-14T19:34:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/\"},\"wordCount\":164,\"publisher\":{\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/vaccines.phila.gov\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/Screenshot-2025-11-13-093028.png\",\"articleSection\":[\"Clinical Updates\",\"COVID-19\",\"General\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/\",\"url\":\"https:\\\/\\\/vaccines.phila.gov\\\/index.php\\\/updated-clinical-guidance-for-covid-19-vaccine\\\/\",\"name\":\"Updated Clinical Guidance for COVID-19 Vaccine - 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Review the tables (previewed below)&nbsp;on this CDC webpage&nbsp;for a deeper dive into these changes. 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